Genes linked to breast cancer tumors

This study was helped by data from Generation Scotland volunteers, which allowed scientists to conduct research into how specific breast cancer tumors are linked to genes. This has the potential to refine genetic testing and predict breast cancer risk in individuals.

This study was conducted by the Breast Cancer Association Consortium, led by researchers at the University of Cambridge.

Research Summary

This international study investigated nine genes previously associated with breast cancer susceptibility, and how these genes are linked to features of tumors. 

These nine genes included: ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, RAD51C, RAD51D and TP53

The huge study included 42,680 patients and 46,387 control volunteers (without cancer), and found that the 9 genes all differed in the features of the tumours, and were often linked to more aggressive cancer types, such as ones called triple-negative and high-grade tumours. 

This research has the potential to improve genetic testing and risk prediction for individuals.

 

Research Visual

Genes linked to breast cancer
Our volunteers have helped in a large study which identified 9 genes linked to the risk of developing breast cancer.
Each gene also linked to a different type of tumour. This could help create specific treatments for types of breast cancer and faster prevention strategies.

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