Find out more about how Generation Scotland works and how a collaboration can support your research. Image We aim to provide researchers around the world with a resource that enables scientific discoveries and improves health knowledge and disease treatments. We aim to inform and influence health policy through rigorous scientific evidence to improve lives. Generation Scotland has recruited participants through two main phases, GS initial recruitment (2006-2011) and NextGenScot (2022-2025) with over 40,000 participants in total. The NextGenScot phase extends to younger generations from 12+ years. The cohort reflects Scotland’s urban–rural and island population distribution and aligns well with national ethnicity data, particularly among younger participants. Notably, around 25% of volunteers come from the 40% most socioeconomically deprived areas. Data from the NextGenScot phase will be available to researchers soon.Generation Scotland combines responses to questionnaires on health and well-being from birth through life. We combine this with NHS health records and innovative laboratory science to understand health trajectories. We work closely with researchers and our volunteers to create a rich evidence base for understanding health. Through this rigorous, ethical and safe approach to research, we seek to enable meaningful change in public health. What makes Generation Scotland unique? Multi-generational family cohortClinical visit and questionnaire dataConsent for recontact of participantsLinkage to the rich and long-standing medical records in ScotlandGenetic and biological measuresCollaborative approach to open science researchAgile response to new initiativesWork with commercial and academic partners to pilot new technologies This article was published on 2024-05-06